Baron, risking our interacting again, I can perhaps offer a bit of information as well.
I am currently two years into a three year clinical study with UCSF, having a device implanted in one eye (I don’t know which one) as a potential treatment to curb the progression of retinitis pigmentosa (blindness).
This past Wednesday, during an examination, I asked the doctor heading up the study (a leader in this area of research) about my time in front of the computer, and why I was experiencing long periods of readjusting when taking breaks (I also wear glasses). In my case, the rods and cones (or what’s left of the active center ones) take a very long time to settle after staring at a screen.
She explained that for all of us, the retinas are literally “bleached” when staring at illuminated displays, albeit temporarily, and not with any lasting effects (I assume she means primarily LEDs). Obviously, as she indicated, things like fatigue and response after staring at a screen will vary according to the age, health, and other factors for different people. In my case, she recommended also trying to make the ambient light in my studio as even as possible.
I suspect other things mentioned in this thread, like tinted glasses or adjusting the contrast and brightness of the monitors themselves may be useful for some, though cannot speak to those things specifically.