Ex HP career guy here,yet currently running (3) Win10 Pro Desktop systems built long ago. Really not that techy with today's advances, but can build heckuva new system in your HP Z Workstation cost range.
You know best if you can justify time and effort to build vs turnkey system. Small town here, but great local PC repair shop has kept me out of trouble so I purchase what I can there.
Favor server cases, lotsa cooling, big power supplies ...... max processor / max DDR4 / mostly Internal SSD(s).
Just now switching out smaller internal HDD(s) to Barracuda Pro 10-12 TB _ to free SATA slots. Will keep most older Libs external. Now going with 4 TB SSD(s) _ QVO fine so far.
Sorry for divergent Reply __ but imminent round of Updating soon, and will build again to use every preferred component vs turnkey compromises.
Regards