I just picked up an i9 9940x which has 14 cores. I used to be able to run an old Dell 8700 desktop with a 4 core processor at 3 GHz, 64 GB of RAM, a couple SSDs, an GTX 970, a Lynx AES16e, outboard reverbe, running a very large template (2700+ midi channels, 18-ish VEP instances) in Nuendo 8 with 2 VEP slaves, all at a 256 buffer, sometimes at 128. With more activity in the session, sometimes I'd need to bump it up to 512. Nuendo's ASIO meter is usually about 2/3rds the way up. On the new, arguably beefier machine - 14 cores at 3.3 GHz, 128 gb ram, AMD GPU, more ssds, same DAW, VEP slaves and hardware... 256 gives me pops and clicks with just a piano patch, so it's up to 512. Asio meter is barely 18% and never red lines. Not sure what it is. In reviews on Anandtech, I've seen indications that DPC latency is generally higher on the x299 chipset than on say, Z390. If I had to guess I'd say it's that the drivers are immature and the hardware is too new. Hopefully over time this improves, but who knows?