We are just finishing a nearly all modular score. Not some indie, but a big, commercial film. It's been such a great, but time consuming experience. It's very different than thinking about the normal palette of strings, woods, brass, perc. It's a far more 'painterly' and expressionistic experience. And the best part is sort of the worst: you are quite literally building the instrument for each note. And you can't safe the pre-sets, so you're always starting from scratch. We are about three months past the original schedule, but we have a super supportive director and music department at the film-studio.
People used to do synth scores to save money. Trust me, that time is gone (actually, "Bladerunner" and "Midnight Express" where already taking electronic scores seriously). A good electronic score is much more expensive than a few days on a scoring stage with a standard orchestral line-up...
There are truly an amazing amount of modules out there and the quality is getting really good. Not just sonically, but solid builds. This is absolutely the time for adventureous synthesis. There have never been as many manufacturers building original and inspiring modules. Of course, the same goes for plug-ins and software synth, but there is something glorious about the home-made quality of modular synthesis for me. And it's important to remember that some decent analog outboard is part of the deal. You need really good a to d's good pre-amps, different compressors and eq's to really take advantage of your modules - so include that in your budgets and setup...