two that stood out for me - but they can be worked around:
(1) video
on one machine, DP would not play back the video, and right click or video specific functionality did not work. it has to do with hardware on that machine that DP has an issue with. This is a very weird issue that some had for years and DP never figured it out (see old posts on motunation). on two other low spec machines, same video, same DP version, same Windows OS, everything worked just fine...
the workaround is to use an external video solution which I'd used anyways sooner or later to not have the DAW handle video and save CPU resources... because u need CPU for everything else if u run large templates
(2) Sequence view not accessible
this happens if u have a lot of AUX or MIDI tracks. see the thread on motunation (earlier this year). so the sequence view will not be accessible at one point (once u go over a certain MIDI + AUX count. ~ 790), but u need it to do AUX track automation, or at least do it properly with a visual overview...
workaround (if u know u'll go high in total track count): open the sequence view at the beginning of the project and only select a few tracks in the track selector (only those will be shown then). by default DP selects ALL tracks and tries to show them. this is what jacks up this view when u go over a certain track number... but since the view saves ur last track select state, if u only select a few tracks to view, the Sequence view tab will always open and work ('cause u never need to see all 790 MIDI and AUX tracks simultaneously)...
if u are already on a project that has already a lot of tracks and the view does not work anymore, save some of the tracks in the the exportable snippet (forgot what it's called), delete those tracks until u get under the "track limit" that jacks up the view, enter the view, deselect all tracks and only select what u need to see and now re-import the tracks u deleted from the snippet...
one the sequence view is set up, it will stay this way until u make changes to the track selector in the sequence view (if u don't select more than 790 it won't be an issue)... trick is to not select more tracks than this "limit"... (read the motunation thread for details)
I'd advise to use VEPro for handling orchestral libs and/or plugins... I've seen the processing bar jump to red (and stay at red) with 500 empty AUX tracks and a single reverb on the master bus... no music playing at all... doesn't make any sense... having the reverb (and other mastering plugs) in VEPro solves all of that and keeps CPU strain away from the DAW...
visual appearance: the scaling of the text font in the GUI is annoying in the Windows version, much nicer in the Mac version... but u'll get over that very fast... (got bigger fish to fry)
HTH