I'm bit late to the party, but:
One machine - AMD 3900XT (12-core), 128 GB RAM, 7 TB of SSD's, 8 TB of HDD's
All orchestral stuff in VEP, everything else in Cubase.
Everything disabled and purged (if possible).
VEP template size is ~1000 MB
Cubase template size is ~800 MB
I use VEP mainly due...